Ontology highlight
ABSTRACT:
SUBMITTER: Lee YS
PROVIDER: S-EPMC2732834 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Lee Yong-Seok YS Choi Sun-Lim SL Lee Seung-Hee SH Kim Hyoung H Park Hyungju H Lee Nuribalhae N Lee Sue-Hyun SH Chae Yeon-Su YS Jang Deok-Jin DJ Kandel Eric R ER Kaang Bong-Kiun BK
Proceedings of the National Academy of Sciences of the United States of America 20090811 34
Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system. In Aplysia sensory neurons, 5-HT can activate several signal cascades, including PKA and PKC, presumably via distinct types of G protein-coupled receptors. However, the molecular identities of these receptors have not yet been identified. We here report the cloning and functional characterization of a 5-HT receptor that is positively coupled to adenylyl cycl ...[more]