Ontology highlight
ABSTRACT:
SUBMITTER: Qi Q
PROVIDER: S-EPMC5871875 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Qi Qi Q Obianyo Obiamaka O Du Yuhong Y Fu Haian H Li Shiyong S Ye Keqiang K
Journal of medicinal chemistry 20170818 17
Asparagine endopeptidase (AEP), also called legumain, is highly expressed in various solid tumors, promoting cancer cell invasion, migration, and metastasis. It has been proposed to be a prognostic marker and therapeutic target for cancer treatment. However, an effective nonpeptide, small-molecule inhibitor against this protease has not yet been identified. Here we show that a family of xanthine derivatives selectively inhibit AEP and suppress matrix metalloproteinase (MMP) cleavage, leading to ...[more]