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Genetic Predictors of ?5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects.


ABSTRACT: Weight loss success is determined by genetic factors, which may differ according to treatment strategy.From a multidisciplinary obesity treatment program involving dietary advice, psychological counseling, and increased physical activity, 587 subjects (68% female; 46.1 ± 12.4 years; BMI 39.9 ± 6.3) were recruited. At baseline, a blood sample was drawn for DNA isolation. Genotypes were determined for 30 polymorphisms in 25 candidate genes. The association between genotypes and weight loss was assessed after 3 months (short-term) and after 12 months of treatment (long-term). Weight loss was categorized as ?5% or <5% of initial weight.The G/G genotype of PLIN1 (rs2289487) and PLIN1 (rs2304795), the T/T genotype of PLIN1 (rs1052700), and the C/C genotype of MMP2 predicted ?5% weight loss in the first 3 months. The C/G-G/G genotype of PPAR? (rs1801282) and the T/C genotype of TIMP4 (rs3755724) predicted ?5% weight loss after 12 months. Subjects with the combination of PPAR? (rs1801282) C/G-G/G and TIMP4 (rs3755724) T/C lost even more weight.Polymorphisms in genes related to regulation of fat storage and structural adaptation of the adipocytes are predictors for weight loss success with different genes being relevant for short-term and long-term weight loss success.

SUBMITTER: Aller EEJG 

PROVIDER: S-EPMC5872564 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects.

Aller Erik E J G EEJG   Mariman Edwin C M ECM   Bouwman Freek G FG   van Baak Marleen A MA  

Journal of nutrigenetics and nutrigenomics 20170603 1-2


<h4>Background</h4>Weight loss success is determined by genetic factors, which may differ according to treatment strategy.<h4>Methods</h4>From a multidisciplinary obesity treatment program involving dietary advice, psychological counseling, and increased physical activity, 587 subjects (68% female; 46.1 ± 12.4 years; BMI 39.9 ± 6.3) were recruited. At baseline, a blood sample was drawn for DNA isolation. Genotypes were determined for 30 polymorphisms in 25 candidate genes. The association betwee  ...[more]

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