Ontology highlight
ABSTRACT:
SUBMITTER: Mouly E
PROVIDER: S-EPMC5873234 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Mouly Enguerran E Ghamlouch Hussein H Della-Valle Veronique V Scourzic Laurianne L Quivoron Cyril C Roos-Weil Damien D Pawlikowska Patrycja P Saada Véronique V Diop M'Boyba K MK Lopez Cécile K CK Fontenay Michaela M Dessen Philippe P Touw Ivo P IP Mercher Thomas T Aoufouchi Said S Bernard Olivier A OA
Blood advances 20180301 6
The <i>TET2</i> gene encodes an α-ketoglutarate-dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. <i>TET2</i> is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies. <i>TET2</i> somatic mutations are also identified in healthy elderly individuals with clonal hematopoiesis. <i>Tet2</i>-deficient mouse models showed widespread hematological differentiation abnormalities, including myel ...[more]