Ca2+ Release Channels Join the 'Resolution Revolution'.
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ABSTRACT:
SUBMITTER: Zalk R
PROVIDER: S-EPMC5875148 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Ca<sup>2+</sup> Release Channels Join the 'Resolution Revolution'.
Trends in biochemical sciences 20170509 7
Ryanodine receptors (RyRs) are calcium release channels expressed in the sarcoendoplasmic reticula of many cell types including cardiac and skeletal muscle cells. In recent years Ca<sup>2+</sup> leak through RyRs has been implicated as a major contributor to the development of diseases including heart failure, muscle myopathies, Alzheimer's disease, and diabetes, making it an important therapeutic target. Recent mammalian RyR1 cryoelectron microscopy (cryo-EM) structures of multiple functional s ...[more]
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