Ontology highlight
ABSTRACT:
SUBMITTER: Zagoraiou L
PROVIDER: S-EPMC58754 | biostudies-literature | 2001 Sep
REPOSITORIES: biostudies-literature
Zagoraiou L L Drabek D D Alexaki S S Guy J A JA Klinakis A G AG Langeveld A A Skavdis G G Mamalaki C C Grosveld F F Savakis C C
Proceedings of the National Academy of Sciences of the United States of America 20010918 20
Transposable elements have been used widely in the past 20 years for gene transfer and insertional mutagenesis in Drosophila. Transposon-based technology for gene manipulation and genomic analysis currently is being adopted for vertebrates. We tested the ability of Minos, a DNA transposon from Drosophila hydei, to transpose in mouse tissues. Two transgenic mouse lines were crossed, one expressing Minos transposase in lymphocytes under the control of the CD2 promoter/locus control region and anot ...[more]