Dataset Information

The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

ABSTRACT: Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging.The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls.Longitudinal cohort study of HIV-positive subjects ?45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years.Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM.The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.

SUBMITTER: De Francesco D

PROVIDER: S-EPMC5875743 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

De Francesco Davide D Wit Ferdinand W FW Cole James H JH Kootstra Neeltje A NA Winston Alan A Sabin Caroline A CA Underwood Jonathan J van Zoest Rosan A RA Schouten Judith J Kooij Katherine W KW Prins Maria M Guaraldi Giovanni G Caan Matthan W A MWA Burger David D Franceschi Claudio C Libert Claude C Bürkle Alexander A Reiss Peter P

PloS one 20180329 3

<h4>Background</h4>Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging.<h4>Objective</h4>The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in ...[more]

PMID: 29596425

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Dataset Information

The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

Publications

The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

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