Dataset Information

The Sister Study Cohort: Baseline Methods and Participant Characteristics.

ABSTRACT: BACKGROUND:The Sister Study was designed to address gaps in the study of environment and breast cancer by taking advantage of more frequent breast cancer diagnoses among women with a sister history of breast cancer and the presumed enrichment of shared environmental and genetic exposures. OBJECTIVE:The Sister Study sought a large cohort of women never diagnosed with breast cancer but who had a sister (full or half) diagnosed with breast cancer. METHODS:A multifaceted national effort employed novel strategies to recruit a diverse cohort, and collected biological and environmental samples and extensive data on potential breast cancer risk factors. RESULTS:The Sister Study enrolled 50,884 U.S. and Puerto Rican women 35-74y of age (median 56 y). Although the majority were non-Hispanic white, well educated, and economically well off, substantial numbers of harder-to-recruit women also enrolled (race/ethnicity other than non-Hispanic white: 16%; no college degree: 35%; household income <$50,000: 26%). Although all had a biologic sister with breast cancer, 16.5% had average or lower risk of breast cancer according to the Breast Cancer Risk Assessment Tool (Gail score). Most were postmenopausal (66%), parous with a first full-term pregnancy <30y of age (79%), never-smokers (56%) with body mass indexes (BMIs) of <29.9?kg/m2 (70%). Few (5%) reported any cancer prior to enrollment. CONCLUSIONS:The Sister Study is a unique cohort designed to efficiently study environmental and genetic risk factors for breast cancer. Extensive exposure data over the life-course and baseline specimens provide important opportunities for studying breast cancer and other health outcomes in women. Collaborations are welcome. https://doi.org/10.1289/EHP1923.

SUBMITTER: Sandler DP

PROVIDER: S-EPMC5963586 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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The Sister Study Cohort: Baseline Methods and Participant Characteristics.

Sandler Dale P DP Hodgson M Elizabeth ME Deming-Halverson Sandra L SL Juras Paula S PS D'Aloisio Aimee A AA Suarez Lourdes M LM Kleeberger Cynthia A CA Shore David L DL DeRoo Lisa A LA Taylor Jack A JA Weinberg Clarice R CR

Environmental health perspectives 20171220 12

<h4>Background</h4>The Sister Study was designed to address gaps in the study of environment and breast cancer by taking advantage of more frequent breast cancer diagnoses among women with a sister history of breast cancer and the presumed enrichment of shared environmental and genetic exposures.<h4>Objective</h4>The Sister Study sought a large cohort of women never diagnosed with breast cancer but who had a sister (full or half) diagnosed with breast cancer.<h4>Methods</h4>A multifaceted nation ...[more]

PMID: 29373861

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Dataset Information

The Sister Study Cohort: Baseline Methods and Participant Characteristics.

Publications

The Sister Study Cohort: Baseline Methods and Participant Characteristics.

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