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A rapid T1 mapping method for assessment of murine kidney viability using dynamic manganese-enhanced magnetic resonance imaging.


ABSTRACT: PURPOSE:Dynamic manganese-enhanced MRI (MEMRI) allows assessment of tissue viability by tracing manganese uptake. We aimed to develop a rapid T1 mapping method for dynamic MEMRI to facilitate assessments of murine kidney viability. METHODS:A multi-slice saturation recovery fast spin echo (MSRFSE) was developed, validated, and subsequently applied in dynamic MEMRI at 16.4T on ischemic mouse kidneys after 4 weeks of unilateral renal artery stenosis (RAS). Baseline T1 values and post-contrast R1 (1/T1 ) changes were measured in cortex (CO), outer (OSOM), inner (ISOM) strips of outer medulla, and inner medulla (IM). RESULTS:Validation studies showed strong agreement between MSRFSE and an established saturation recovery Look-Locker method. Baseline T1 (s) increased in the stenotic kidney CO (2.10 [1.95-2.56] vs. 1.88 [1.81-2.00], P?=?0.0317) and OSOM (2.17 [2.05-2.33] vs. 1.96 [1.87-2.00], P?=?0.0075) but remained unchanged in ISOM and IM. This method allowed a temporal resolution of 1.43?min in dynamic MEMRI. Mn2+ uptake and retention decreased in stenotic kidneys, particularly in the OSOM (?R1 : 0.48 [0.38-0.56] vs. 0.64 [0.61-0.69] s-1 , P?

SUBMITTER: Jiang K 

PROVIDER: S-EPMC5876081 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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A rapid T<sub>1</sub> mapping method for assessment of murine kidney viability using dynamic manganese-enhanced magnetic resonance imaging.

Jiang Kai K   Tang Hui H   Mishra Prasanna K PK   Macura Slobodan I SI   Lerman Lilach O LO  

Magnetic resonance in medicine 20171128 1


<h4>Purpose</h4>Dynamic manganese-enhanced MRI (MEMRI) allows assessment of tissue viability by tracing manganese uptake. We aimed to develop a rapid T<sub>1</sub> mapping method for dynamic MEMRI to facilitate assessments of murine kidney viability.<h4>Methods</h4>A multi-slice saturation recovery fast spin echo (MSRFSE) was developed, validated, and subsequently applied in dynamic MEMRI at 16.4T on ischemic mouse kidneys after 4 weeks of unilateral renal artery stenosis (RAS). Baseline T<sub>1  ...[more]

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