Ontology highlight
ABSTRACT:
SUBMITTER: Wuttke TV
PROVIDER: S-EPMC5876138 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wuttke Thomas V TV Markopoulos Foivos F Padmanabhan Hari H Wheeler Aaron P AP Murthy Venkatesh N VN Macklis Jeffrey D JD
Nature neuroscience 20180305 4
Repair of complex CNS circuitry requires newly incorporated neurons to become appropriately, functionally integrated. One approach is to direct differentiation of endogenous progenitors in situ, or ex vivo followed by transplantation. Prior studies find that newly incorporated neurons can establish long-distance axon projections, form synapses and functionally integrate in evolutionarily old hypothalamic energy-balance circuitry. We now demonstrate that postnatal neocortical connectivity can be ...[more]