Ontology highlight
ABSTRACT:
SUBMITTER: Ren YB
PROVIDER: S-EPMC5876919 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ren Yan-Bei YB Sun Shang-Jun SJ Han Shuang-Yin SY
Current pharmaceutical design 20180101 1
T-cell therapy using genetically engineered T cells modified with either T cell receptor or chimeric antigen receptor holds great promise for cancer immunotherapy. The concerns about its toxicities still remain despite recent successes in clinical trials. Temporal and spatial control of the engineered therapeutic T cells may improve the safety profile of these treatment regimens. To achieve these goals, numerous approaches have been tested and utilized including the incorporation of a suicide ge ...[more]