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Genetically engineered T cells for cancer immunotherapy.

ABSTRACT: T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy, by relying on this basic recognition method, boosts the antitumor efficacy of T cells by unleashing the inhibition of immune checkpoints and expands adaptive immunity by facilitating the adoptive transfer of genetically engineered T cells. T cells genetically equipped with chimeric antigen receptors (CARs) or TCRs have shown remarkable effectiveness in treating some hematological malignancies, although the efficacy of engineered T cells in treating solid tumors is far from satisfactory. In this review, we summarize the development of genetically engineered T cells, outline the most recent studies investigating genetically engineered T cells for cancer immunotherapy, and discuss strategies for improving the performance of these T cells in fighting cancers.

SUBMITTER: Li D

PROVIDER: S-EPMC6799837 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Genetically engineered T cells for cancer immunotherapy.

Li Dan D Li Xue X Zhou Wei-Lin WL Huang Yong Y Liang Xiao X Jiang Lin L Yang Xiao X Sun Jie J Li Zonghai Z Han Wei-Dong WD Wang Wei W

Signal transduction and targeted therapy 20190920

T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy, by relying on this basic recognition method, boosts the antitumor efficacy of T cells by unleashing the inhibition of immune checkpoints and expands adaptive immunity by facilitating the adoptive transfer of genetically engineered T cells. T cells genetically equipped with chimeric antigen receptors (CARs) or TCRs ha ...[more]

PMID: 31637014

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