Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC6799837 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Signal transduction and targeted therapy 20190920
T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy, by relying on this basic recognition method, boosts the antitumor efficacy of T cells by unleashing the inhibition of immune checkpoints and expands adaptive immunity by facilitating the adoptive transfer of genetically engineered T cells. T cells genetically equipped with chimeric antigen receptors (CARs) or TCRs ha ...[more]