Ontology highlight
ABSTRACT:
SUBMITTER: Jenul C
PROVIDER: S-EPMC5878181 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Jenul Christian C Sieber Simon S Daeppen Christophe C Mathew Anugraha A Lardi Martina M Pessi Gabriella G Hoepfner Dominic D Neuburger Markus M Linden Anthony A Gademann Karl K Eberl Leo L
Nature communications 20180330 1
Members of the diazeniumdiolate class of natural compounds show potential for drug development because of their antifungal, antibacterial, antiviral, and antitumor activities. Yet, their biosynthesis has remained elusive to date. Here, we identify a gene cluster directing the biosynthesis of the diazeniumdiolate compound fragin in Burkholderia cenocepacia H111. We provide evidence that fragin is a metallophore and that metal chelation is the molecular basis of its antifungal activity. A subset o ...[more]