Ontology highlight
ABSTRACT:
SUBMITTER: Yukata K
PROVIDER: S-EPMC5878736 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yukata Kiminori K Xie Chao C Li Tian-Fang TF Brown Matthew L ML Kanchiku Tsukasa T Zhang Xinping X Awad Hani A HA Schwarz Edward M EM Beck Christopher A CA Jonason Jennifer H JH O'Keefe Regis J RJ
Bone 20180203
Genetic ablation of cyclooxygenase-2 (COX-2) in mice is known to impair fracture healing. To determine if teriparatide (human PTH<sub>1-34</sub>) can promote healing of Cox-2-deficient fractures, we performed detailed in vivo analyses using a murine stabilized tibia fracture model. Periosteal progenitor cell proliferation as well as bony callus formation was markedly reduced in Cox-2<sup>-/-</sup> mice at day 10 post-fracture. Remarkably, intermittent PTH<sub>1-34</sub> administration increased ...[more]