Ontology highlight
ABSTRACT:
SUBMITTER: Naik AA
PROVIDER: S-EPMC3276605 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Naik Amish A AA Xie Chao C Zuscik Michael J MJ Kingsley Paul P Schwarz Edward M EM Awad Hani H Guldberg Robert R Drissi Hicham H Puzas J Edward JE Boyce Brendan B Zhang Xinping X O'Keefe Regis J RJ
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20090201 2
The cellular and molecular events responsible for reduced fracture healing with aging are unknown. Cyclooxygenase 2 (COX-2), the inducible regulator of prostaglandin E(2) (PGE(2)) synthesis, is critical for normal bone repair. A femoral fracture repair model was used in mice at either 7-9 or 52-56 wk of age, and healing was evaluated by imaging, histology, and gene expression studies. Aging was associated with a decreased rate of chondrogenesis, decreased bone formation, reduced callus vasculari ...[more]