Ontology highlight
ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC5880160 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Chen Ming M Pandolfi Pier Paolo PP
Cold Spring Harbor perspectives in medicine 20180402 4
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage prostate cancer (PCa). Insights from the mCRPC genomic landscape have revealed that, in addition to sustained androgen receptor (AR) signaling, there are other actionable molecular alterations and distinct molecular subclasses of PCa; however, the rate at which this knowledge ...[more]