Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex.
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ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC5880816 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex.
Xie Long L Das Sandhitsu R SR Wisse Laura E M LEM Ittyerah Ranjit R Yushkevich Paul A PA Wolk David A DA
Journal of Alzheimer's disease : JAD 20180101 1
Neurofibrillary tangle (NFT) pathology is linked to neurodegeneration in the medial temporal lobe (MTL). Using a tailored pipeline, we correlated atrophy rate, as measured from retrospective longitudinal MRI, with NFT burden, measured from 18F-AV-1451 PET, within MTL regions of earliest NFT pathology. In amyloid-β positive but not amyloid-β negative individuals, we found significant correlation between 18F-AV-1451 uptake and atrophy rate that was strongest in the transentorhinal cortex, the firs ...[more]
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