Structural mechanisms of CFTR function and dysfunction.
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ABSTRACT:
SUBMITTER: Hwang TC
PROVIDER: S-EPMC5881446 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Structural mechanisms of CFTR function and dysfunction.
Hwang Tzyh-Chang TC Yeh Jiunn-Tyng JT Zhang Jingyao J Yu Ying-Chun YC Yeh Han-I HI Destefano Samantha S
The Journal of general physiology 20180326 4
Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a critical role in regulating transepithelial movement of water and electrolyte in exocrine tissues. Malfunction of the channel because of mutations of the <i>cftr</i> gene results in CF, the most prevalent lethal genetic disease among Caucasians. Recently, the publication of atomic structures of CFTR in two distinct conformations provides, for the first time, a clear overview of the protein. However, given th ...[more]
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