Ontology highlight
ABSTRACT:
SUBMITTER: Backes S
PROVIDER: S-EPMC5881500 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Backes Sandra S Hess Steffen S Boos Felix F Woellhaf Michael W MW Gödel Sabrina S Jung Martin M Mühlhaus Timo T Herrmann Johannes M JM
The Journal of cell biology 20180130 4
The biogenesis of mitochondria depends on the import of hundreds of preproteins. N-terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20, Tom22, and Tom70. In this study, we show that many preproteins contain additional internal MTS-like signals (iMTS-Ls) in their mature region that share the characteristic properties of presequences. These features allow the in silico prediction of iMTS-Ls. Using Atp1 as model substrate, we show that iMTS-Ls mediate the bind ...[more]