Ontology highlight
ABSTRACT:
SUBMITTER: Wegmann S
PROVIDER: S-EPMC5881631 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wegmann Susanne S Eftekharzadeh Bahareh B Tepper Katharina K Zoltowska Katarzyna M KM Bennett Rachel E RE Dujardin Simon S Laskowski Pawel R PR MacKenzie Danny D Kamath Tarun T Commins Caitlin C Vanderburg Charles C Roe Allyson D AD Fan Zhanyun Z Molliex Amandine M AM Hernandez-Vega Amayra A Muller Daniel D Hyman Anthony A AA Mandelkow Eckhard E Taylor J Paul JP Hyman Bradley T BT
The EMBO journal 20180222 7
The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid-liquid phase separation (LLPS) under cellular conditions and that phase-separated tau droplets can serve as an intermediate toward tau aggregate formation. We demonstrate that phosphorylated or mutant aggregation prone recombinant tau undergoes LLPS, as does high molecular weight soluble p ...[more]