Ontology highlight
ABSTRACT:
SUBMITTER: Boyko S
PROVIDER: S-EPMC6643045 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Boyko Solomiia S Qi Xu X Chen Tien-Hao TH Surewicz Krystyna K Surewicz Witold K WK
The Journal of biological chemistry 20190516 29
Recent studies have indicated that tau, a protein involved in Alzheimer's disease and other neurodegenerative disorders, has a propensity to undergo liquid-liquid phase separation (LLPS). However, the mechanism of this process remains unknown. Here, we demonstrate that tau LLPS is largely driven by intermolecular electrostatic interactions between the negatively charged N-terminal and positively charged middle/C-terminal regions, whereas hydrophobic interactions play a surprisingly small role. F ...[more]