Ontology highlight
ABSTRACT:
SUBMITTER: Godwin RC
PROVIDER: S-EPMC5882596 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Godwin Ryan C RC Gmeiner William H WH Salsbury Freddie R FR
Journal of biomolecular structure & dynamics 20171003 10
An important regulatory domain of NF-[Formula: see text]B Essential Modulator (NEMO) is a ubiquitin-binding zinc finger, with a tetrahedral CYS3HIS1 zinc-coordinating binding site. Two variations of NEMO's zinc finger are implicated in various disease states including ectodermal dysplasia and adult-onset glaucoma. To discern structural and dynamical differences between these disease states, we present results of 48-[Formula: see text]s of molecular dynamics simulations for three zinc finger syst ...[more]