Ontology highlight
ABSTRACT:
SUBMITTER: Workman AD
PROVIDER: S-EPMC5882797 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Workman Alan D AD Maina Ivy W IW Brooks Steven G SG Kohanski Michael A MA Cowart Beverly J BJ Mansfield Corrine C Kennedy David W DW Palmer James N JN Adappa Nithin D ND Reed Danielle R DR Lee Robert J RJ Cohen Noam A NA
Frontiers in immunology 20180328
<h4>Background</h4>Bitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis (CRS). Quinine is a bitter compound that is an agonist for several T2Rs also expressed on sinonasal cells, but not for T2R38. Because of this property, quinine may stimulate innate immune defense mechanisms in the airway, and functional di ...[more]