Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5883120 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Wang Yiru Y Li Yan Y Yang Wenyu W Gao Shiyu S Lin Jianwei J Wang Tianqi T Zhou Kailiang K Hu Haiyan H
American journal of translational research 20180315 3
Alzheimer's disease (AD) is the most common form of dementia and lacks disease-altering treatments. Ginsenoside Rb1 (GsRb1), the key active compounds of ginsenoside found in ginseng. The present study aimed to determine whether GsRb1 could prevent cognitive deficit and take neuroprotective effects in Aβ<sub>1-40</sub>-induced rat model through apoptotic signaling pathway. Injection of soluble Aβ<sub>1-40</sub> into the hippocampus caused impairment in learning and memory. Daily administration of ...[more]