Ontology highlight
ABSTRACT:
SUBMITTER: Chen TL
PROVIDER: S-EPMC5884014 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chen Tai-Lin TL Lin Yi-Wen YW Chen Yan-Bo YB Lin Jing-Jer JJ Su Tsann-Long TL Shen Chia-Ning CN Lee Te-Chang TC
Neoplasia (New York, N.Y.) 20171213 2
Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti-colorectal cancer (CRC) activity of SL-1, a DNA-directed N-mustard-quinoline conjugate. The N-mustard moiety in SL-1 induced DNA strand breaks, interstrand cross-links (ICLs), G2/M arrest, and apoptosis, whereas its quinoline moiety preferentially directed SL-1 to target the selective guanine sequence 5'-G-G/C-N-G-C/T-3'. Notably, SL-1 was highly cytotoxic to various CRC ...[more]