APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
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ABSTRACT:
SUBMITTER: Saito-Diaz K
PROVIDER: S-EPMC5884143 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
Saito-Diaz Kenyi K Benchabane Hassina H Tiwari Ajit A Tian Ai A Li Bin B Thompson Joshua J JJ Hyde Annastasia S AS Sawyer Leah M LM Jodoin Jeanne N JN Santos Eduardo E Lee Laura A LA Coffey Robert J RJ Beauchamp R Daniel RD Williams Christopher S CS Kenworthy Anne K AK Robbins David J DJ Ahmed Yashi Y Lee Ethan E
Developmental cell 20180301 5
Adenomatous polyposis coli (APC) mutations cause Wnt pathway activation in human cancers. Current models for APC action emphasize its role in promoting β-catenin degradation downstream of Wnt receptors. Unexpectedly, we find that blocking Wnt receptor activity in APC-deficient cells inhibits Wnt signaling independently of Wnt ligand. We also show that inducible loss of APC is rapidly followed by Wnt receptor activation and increased β-catenin levels. In contrast, APC2 loss does not promote recep ...[more]
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