Dataset Information

Dementia and vagotomy in Taiwan: a population-based cohort study.

ABSTRACT: OBJECTIVE:Truncal vagotomy is associated with a decreased risk of subsequent Parkinson disease (PD), although the effect of vagotomy on dementia is unclear. In response, we investigated the risk of dementia in patients who underwent vagotomy. SETTING:Population-based cohort study. PARTICIPANTS:A total of 155?944 patients who underwent vagotomy (vagotomy cohort) and 155?944 age-matched, sex-matched and comorbidity-matched controls (non-vagotomy cohort) were identified between 2000 and 2011. PRIMARY AND SECONDARY OUTCOME MEASURES:All patient data were tracked until the diagnosis of dementia, death or the end of 2011. The cumulative incidence of subsequent dementia and HRs were calculated. RESULTS:The mean ages of the study patients in the vagotomy and non-vagotomy cohorts were 56.6±17.4?and 56.7±17.3 years, respectively. The overall incidence density rate for dementia was similar in the vagotomy and non-vagotomy cohorts (2.43 and 2.84 per 1000 person-years, respectively). After adjustment for age, sex and comorbidities such as diabetes, hypertension, hyperlipidaemia, stroke, depression, coronary artery disease and PD, the patients in the vagotomy cohort were determined to not be at a higher risk of dementia than those in the non-vagotomy cohort (adjusted HR=1.09, 95% CI 0.87 to 1.36). Moreover, the patients who underwent truncal vagotomy were not associated with risk of dementia (adjusted HR=1.04, 95%?CI 0.87 to 1.25), compared with the patients who did not undergo vagotomy. CONCLUSION:Vagotomy, either truncal or selective, is not associated with risk of dementia.

SUBMITTER: Lin SY

PROVIDER: S-EPMC5884346 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Dementia and vagotomy in Taiwan: a population-based cohort study.

Lin Shih-Yi SY Lin Cheng-Li CL Wang I-Kuan IK Lin Cheng-Chieh CC Lin Chih-Hsueh CH Hsu Wu-Huei WH Kao Chia-Hung CH

BMJ open 20180330 3

<h4>Objective</h4>Truncal vagotomy is associated with a decreased risk of subsequent Parkinson disease (PD), although the effect of vagotomy on dementia is unclear. In response, we investigated the risk of dementia in patients who underwent vagotomy.<h4>Setting</h4>Population-based cohort study.<h4>Participants</h4>A total of 155 944 patients who underwent vagotomy (vagotomy cohort) and 155 944 age-matched, sex-matched and comorbidity-matched controls (non-vagotomy cohort) were identified betwee ...[more]

PMID: 29602843

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Project description:Dementia is one of the most burdensome illnesses in elderly populations worldwide. However, the literature about multiple risk factors for dementia is scant.To develop a simple, rapid, and appropriate predictive tool for the clinical quantitative assessment of multiple risk factors for dementia.A population-based cohort study.Based on the Taiwan National Health Insurance Research Database, participants first diagnosed with dementia from 2000 to 2009 and aged ?65 years in 2000 were included.A logistic regression model with Bayesian supervised learning inference was implemented to evaluate the quantitative effects of 1- to 6-comorbidity risk factors for dementia in the elderly Taiwanese population: depression, vascular disease, severe head injury, hearing loss, diabetes mellitus (DM), and senile cataract, identified from a nationwide longitudinal population-based database.This study enrolled 4749 (9.5%) patients first diagnosed as having dementia. Aged, female, urban residence, and low income were found as independent sociodemographic risk factors for dementia. Among all odds ratios (ORs) of 2-comorbidity risk factors for dementia, comorbid depression and vascular disease had the highest adjusted OR of 6.726. The 5-comorbidity risk factors, namely depression, vascular disease, severe head injury, hearing loss, and DM, exhibited the highest OR of 8.767. Overall, the quantitative effects of 2 to 6 comorbidities and age difference on dementia gradually increased; hence, their ORs were less than additive. These results indicate that depression is a key comorbidity risk factor for dementia.The present findings suggest that physicians should pay more attention to the role of depression in dementia development. Depression is a key cormorbidity risk factor for dementia. It is the urgency of evaluating the nature of the link between depression and dementia; and further testing what extent controlling depression could effectively lead to the prevention of dementia.

Dataset Information

Dementia and vagotomy in Taiwan: a population-based cohort study.

Publications

Dementia and vagotomy in Taiwan: a population-based cohort study.

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