Nociceptive brain activity as a measure of analgesic efficacy in infants.
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ABSTRACT:
SUBMITTER: Hartley C
PROVIDER: S-EPMC5884430 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Nociceptive brain activity as a measure of analgesic efficacy in infants.
Hartley Caroline C Duff Eugene P EP Green Gabrielle G Mellado Gabriela Schmidt GS Worley Alan A Rogers Richard R Rogers Richard R Slater Rebeccah R
Science translational medicine 20170501 388
Pain in infants is undertreated and poorly understood, representing a major clinical problem. In part, this is due to our inability to objectively measure pain in nonverbal populations. We present and validate an electroencephalography-based measure of infant nociceptive brain activity that is evoked by acute noxious stimulation and is sensitive to analgesic modulation. This measure should be valuable both for mechanistic investigations and for testing analgesic efficacy in the infant population ...[more]
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