Treatment of oral cancer using magnetized paclitaxel.
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ABSTRACT:
SUBMITTER: Nakakaji R
PROVIDER: S-EPMC5884650 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Treatment of oral cancer using magnetized paclitaxel.
Nakakaji Rina R Umemura Masanari M Mitsudo Kenji K Kim Jeong-Hwan JH Hoshino Yujiro Y Sato Itaru I Masuda Takatsugu T Yamamoto Masahiro M Kioi Mitomu M Koizumi Toshiyuki T Fujita Takayuki T Yokoyama Utako U Iida Masaki M Sato Motohiko M Sato Hiroshi H Murofushi Shoko S Shibata Sayaka S Aoki Ichio I Eguchi Haruki H Tohnai Iwai I Ishikawa Yoshihiro Y
Oncotarget 20180226 21
<i>N,N'-Bis(salicylidene)ethylenediamine iron</i> (Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for magnet-guided drug delivery and MRI visualization. M-PTX increased apoptosis and G2/M arrest of cultured human oral cancer cell lines in the same manner as PTX. Furthermore, marked contrast in ...[more]
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