Ontology highlight
ABSTRACT:
SUBMITTER: Nakakaji R
PROVIDER: S-EPMC5884650 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Oncotarget 20180226 21
<i>N,N'-Bis(salicylidene)ethylenediamine iron</i> (Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for magnet-guided drug delivery and MRI visualization. M-PTX increased apoptosis and G2/M arrest of cultured human oral cancer cell lines in the same manner as PTX. Furthermore, marked contrast in ...[more]