Ontology highlight
ABSTRACT:
SUBMITTER: Ahmadian M
PROVIDER: S-EPMC5884669 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ahmadian Maryam M Liu Sihao S Reilly Shannon M SM Hah Nasun N Fan Weiwei W Yoshihara Eiji E Jha Pooja P De Magalhaes Filho C Daniel CD Jacinto Sandra S Gomez Andrew V AV Dai Yang Y Yu Ruth T RT Liddle Christopher C Atkins Annette R AR Auwerx Johan J Saltiel Alan R AR Downes Michael M Evans Ronald M RM
Cell reports 20180301 11
Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive response of BAT are unclear. Here, we identify estrogen-related receptor gamma (ERRγ) as a critical factor for maintaining BAT identity. ERRγ is selectively expressed in BAT versus WAT, in which, in the absence of PGC1α, it drives a signature transcriptional networ ...[more]