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Quarter Century of Anti-HIV CAR T Cells.

ABSTRACT: PURPOSE OF REVIEW:A therapy that might cure HIV is a very important goal for the 30-40 million people living with HIV. Chimeric antigen receptor T cells have recently had remarkable success against certain leukemias, and there are reasons to believe they could be successful for HIV. This manuscript summarizes the published research on HIV CAR T cells and reviews the current anti-HIV chimeric antigen receptor strategies. RECENT FINDINGS:Research on anti-HIV chimeric antigen receptor T cells has been going on for at least the last 25 years. First- and second-generation anti-HIV chimeric antigen receptors have been developed. First-generation anti-HIV chimeric antigen receptors were studied in clinical trials more than 15 years ago, but did not have meaningful clinical efficacy. There are some reasons to be optimistic about second-generation anti-HIV chimeric antigen receptor T cells, but they have not yet been tested in vivo.

SUBMITTER: Wagner TA

PROVIDER: S-EPMC5884727 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Quarter Century of Anti-HIV CAR T Cells.

Wagner Thor A TA

Current HIV/AIDS reports 20180401 2

<h4>Purpose of review</h4>A therapy that might cure HIV is a very important goal for the 30-40 million people living with HIV. Chimeric antigen receptor T cells have recently had remarkable success against certain leukemias, and there are reasons to believe they could be successful for HIV. This manuscript summarizes the published research on HIV CAR T cells and reviews the current anti-HIV chimeric antigen receptor strategies.<h4>Recent findings</h4>Research on anti-HIV chimeric antigen recepto ...[more]

PMID: 29500712

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