Dataset Information

Pathophysiology of Long Non-coding RNAs in Ischemic Stroke.

ABSTRACT: Stroke is a neurological disease with high disability and fatality rates, and ischemic stroke accounts for 75% of all stroke cases. The underlying pathophysiologic processes of ischemic stroke include oxidative stress, toxicity of excitatory amino acids, excess calcium ions, increased apoptosis and inflammation. Long non-coding RNAs (lncRNAs) may participate in the regulation of the pathophysiologic processes of ischemic stroke as indicated by altered expression of lncRNAs in blood samples of acute ischemic stroke patients, animal models of focal cerebral ischemia and oxygen-glucose deprivation (OGD) cell models. Because of the potentially important role, lncRNAs might be useful as biomarkers for the diagnosis, treatment and prognosis of ischemic stroke. This article reviews the functions of lncRNAs in different pathophysiology events of ischemic stroke with a focus on specific lncRNAs that may underlie ischemic stroke pathophysiology and that could therefore serve as potential diagnostic biomarkers and therapeutic targets.

SUBMITTER: Ren W

PROVIDER: S-EPMC5884949 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Pathophysiology of Long Non-coding RNAs in Ischemic Stroke.

Ren Weimin W Yang Xiaobo X

Frontiers in molecular neuroscience 20180329

Stroke is a neurological disease with high disability and fatality rates, and ischemic stroke accounts for 75% of all stroke cases. The underlying pathophysiologic processes of ischemic stroke include oxidative stress, toxicity of excitatory amino acids, excess calcium ions, increased apoptosis and inflammation. Long non-coding RNAs (lncRNAs) may participate in the regulation of the pathophysiologic processes of ischemic stroke as indicated by altered expression of lncRNAs in blood samples of ac ...[more]

PMID: 29651234

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Project description:Long non‑coding RNAs (lncRNAs) represent potential biomarkers for the diagnosis and treatment of various diseases; however, the role of circulating acute ischemic stroke (AIS)‑related lncRNAs remains relatively unknown. The present study aimed to screen crucial lncRNAs for AIS based on the competing endogenous RNA (ceRNA) hypothesis. The expression profile datasets for one mRNA, accession no. GSE16561, and four microRNAs (miRNAs), accession nos. GSE95204, GSE86291, GSE55937 and GSE110993, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs), lncRNAs (DELs), and miRNAs (DEMs) were identified, and ClusterProfiler was used to interpret the function of the DEGs. Based on the protein‑protein interaction (PPI) network and module analyses, hub DEGs were identified. A ceRNA network was established based on miRNA‑mRNA or miRNA‑lncRNA interaction pairs. In total, 2,041 DEGs and 5 DELs were identified between the AIS and controls samples in GSE16561, and 10 DEMs between at least two of the four miRNA expression profiles. A PPI network was constructed with 1,235 DEGs, among which 20 genes were suggested to be hub genes. The hub genes paxillin (PXN), FYN‑proto‑oncogene, Src family tyrosine kinase (FYN), ras homolog family member A (RHOA), STAT1, and growth factor receptor‑bound protein 2 (GRB2), were amongst the most significantly enriched modules extracted from the PPI network. Functional analysis revealed that these hub genes were associated with inflammation‑related signaling pathways. An AIS‑related ceRNA network was constructed, in which 4 DELs were predicted to function as ceRNAs for 9 DEMs, to regulate the five identified hub genes; that is, minichromosome maintenance complex component 3 associated protein‑antisense RNA 1 (MCM3AP‑AS1)/long intergenic non‑protein coding RNA 1089 (LINC01089)/hsa‑miRNA (miR)‑125a/FYN, inositol‑tetrakisphosphate 1‑kinase‑antisense RNA 1 (ITPK1‑AS1)/hsa‑let‑7i/RHOA/GRB2/STAT1, and human leukocyte antigen complex group 27 (HCG27)/hsa‑-miR‑19a/PXN interaction axes. In conclusion, MCM3AP‑AS1, LINC01089, ITPK1‑AS1, and HCG27 may represent new biomarkers and underlying targets for the treatment of AIS.

Dataset Information

Pathophysiology of Long Non-coding RNAs in Ischemic Stroke.

Publications

Pathophysiology of Long Non-coding RNAs in Ischemic Stroke.

Similar Datasets

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