Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC5885592 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chemical science 20171205 5
The first direct C-H <sup>18</sup>F fluorination reaction of unactivated aliphatic sites using no-carrier-added [<sup>18</sup>F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-<sup>18</sup>F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for t ...[more]