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Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp³ C-O Bonds in Cyclic Acetals.

ABSTRACT: A dual catalytic manifold that enables site-selective functionalization of unactivated sp³ C-O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate σ*-p orbital overlap prior to sp³ C-O cleavage, thus highlighting the importance of conformational flexibility in both reactivity and site selectivity. The protocol is characterized by its excellent chemoselectivity profile, thus offering new vistas for activating strong σ sp³ C-O linkages.

SUBMITTER: Romano C

PROVIDER: S-EPMC9264358 | biostudies-literature |

REPOSITORIES: biostudies-literature

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