Potential role of IL-37 in atherosclerosis.
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ABSTRACT:
SUBMITTER: McCurdy S
PROVIDER: S-EPMC5886822 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Potential role of IL-37 in atherosclerosis.
McCurdy Sara S Liu Chloe A CA Yap Jonathan J Boisvert William A WA
Cytokine 20171005
IL-37 is a member of the IL-1 family, but unlike most other members of this family of cytokines, it has wide-ranging anti-inflammatory properties. Initially shown to bind IL-18 binding protein and prevent IL-18-mediated inflammation, its known role has been expanded to include distinct pathways, both intracellular involving the transcription factor Smad3, and extracellular via binding to the orphan receptor IL-1R8. A number of recent publications investigating the role of IL-37 in atherosclerosi ...[more]
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