Ontology highlight
ABSTRACT:
SUBMITTER: Dodd W
PROVIDER: S-EPMC5887142 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Dodd William W Tang Lanlan L Lone Jean-Christophe JC Wimberly Keon K Wu Cheng-Wei CW Consalvo Claudia C Wright Joni E JE Pujol Nathalie N Choe Keith P KP
Genetics 20180227 4
Extracellular matrix barriers and inducible cytoprotective genes form successive lines of defense against chemical and microbial environmental stressors. The barrier in nematodes is a collagenous extracellular matrix called the cuticle. In <i>Caenorhabditis elegans</i>, disruption of some cuticle collagen genes activates osmolyte and antimicrobial response genes. Physical damage to the epidermis also activates antimicrobial responses. Here, we assayed the effect of knocking down genes required f ...[more]