Ontology highlight
ABSTRACT:
SUBMITTER: Cassani C
PROVIDER: S-EPMC5888019 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cassani Corinne C Gobbini Elisa E Vertemara Jacopo J Wang Weibin W Marsella Antonio A Sung Patrick P Tisi Renata R Zampella Giuseppe G Longhese Maria Pia MP
Nucleic acids research 20180401 6
Sae2 cooperates with the Mre11-Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. How these diverse MRX-Sae2 functions contribute to DNA damage resistance is not known. Here, we describe mre11 alleles that suppress the hypersensitivity of sae2Δ cells to genotoxic agents. By assessing the impact of these mutations at the cellular and structural levels, we found that all the mre11 alleles that res ...[more]