Ontology highlight
ABSTRACT:
SUBMITTER: Sinha D
PROVIDER: S-EPMC5888655 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sinha Debajyoti D Kumar Akhilesh A Kumar Himanshu H Bandyopadhyay Sanghamitra S Sengupta Debarka D
Nucleic acids research 20180401 6
Droplet based single cell transcriptomics has recently enabled parallel screening of tens of thousands of single cells. Clustering methods that scale for such high dimensional data without compromising accuracy are scarce. We exploit Locality Sensitive Hashing, an approximate nearest neighbour search technique to develop a de novo clustering algorithm for large-scale single cell data. On a number of real datasets, dropClust outperformed the existing best practice methods in terms of execution ti ...[more]