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Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers.


ABSTRACT: Alcohol misuse is associated with dysfunction of the amygdala-prefrontal cortical circuit. The amygdala and its cortical targets show decreased activity during a variety of task challenges in individuals engaged in problem drinking. On the other hand, it is less clear how amygdala resting state functional connectivity (rsFC) may be altered in association with alcohol misuse and whether such changes are restricted to prefrontal cortical structures. Further, the influences of comorbid substance use and depression and potential sex differences have not been assessed in earlier work. Here, with fMRI data from a Nathan Kline Institute/Rockland sample of 83 non-dependent alcohol drinkers (26 men), we addressed changes in whole brain rsFC of the amygdala in association with problem drinking as indexed by an alcohol involvement score. Imaging data were processed with Statistical Parametric Mapping following standard routines and all results were examined at voxel p?

SUBMITTER: Hu S 

PROVIDER: S-EPMC5889735 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers.

Hu Sien S   Ide Jaime S JS   Chao Herta H HH   Zhornitsky Simon S   Fischer Kimberly A KA   Wang Wuyi W   Zhang Sheng S   Li Chiang-Shan R CR  

Drug and alcohol dependence 20180207


Alcohol misuse is associated with dysfunction of the amygdala-prefrontal cortical circuit. The amygdala and its cortical targets show decreased activity during a variety of task challenges in individuals engaged in problem drinking. On the other hand, it is less clear how amygdala resting state functional connectivity (rsFC) may be altered in association with alcohol misuse and whether such changes are restricted to prefrontal cortical structures. Further, the influences of comorbid substance us  ...[more]

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