Inhibition of Protein Aggregation by Several Antioxidants.
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ABSTRACT:
SUBMITTER: Hasanbasic S
PROVIDER: S-EPMC5889867 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Inhibition of Protein Aggregation by Several Antioxidants.
Hasanbašić Samra S Jahić Alma A Berbić Selma S Žnidarič Magda Tušek MT Žerovnik Eva E
Oxidative medicine and cellular longevity 20180325
Amyloid fibril formation is a shared property of all proteins; therefore, model proteins can be used to study this process. We measured protein aggregation of the model amyloid-forming protein stefin B in the presence and absence of several antioxidants. Amyloid fibril formation by stefin B was routinely induced at pH 5 and 10% TFE, at room temperature. The effects of antioxidants NAC, vitamin C, vitamin E, and the three polyphenols resveratrol, quercetin, and curcumin on the kinetics of fibril ...[more]
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