Ontology highlight
ABSTRACT:
SUBMITTER: Michaels TCT
PROVIDER: S-EPMC6642341 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Michaels Thomas C T TCT Weber Christoph A CA Mahadevan L L
Proceedings of the National Academy of Sciences of the United States of America 20190628 29
Protein aggregation has been implicated in many medical disorders, including Alzheimer's and Parkinson's diseases. Potential therapeutic strategies for these diseases propose the use of drugs to inhibit specific molecular events during the aggregation process. However, viable treatment protocols require balancing the efficacy of the drug with its toxicity, while accounting for the underlying events of aggregation and inhibition at the molecular level. To address this key problem, we combine here ...[more]