Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5889952 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Liu Xiaojing X Romero Iris L IL Litchfield Lacey M LM Lengyel Ernst E Locasale Jason W JW
Cell metabolism 20161013 5
Repurposing metformin for cancer therapy is attractive due to its safety profile, epidemiological evidence, and encouraging data from human clinical trials. Although it is known to systemically affect glucose metabolism in liver, muscle, gut, and other tissues, the molecular determinants that predict a patient response in cancer remain unknown. Here, we carry out an integrative metabolomics analysis of metformin action in ovarian cancer. Metformin accumulated in patient biopsies, and pathways in ...[more]