Ontology highlight
ABSTRACT:
SUBMITTER: Bassetto M
PROVIDER: S-EPMC5890509 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Bassetto Marcella M Ferla Salvatore S Leyssen Pieter P Neyts Johan J Yerukhimovich Mark M MM Frick David N DN O'Donnell Rachel R Brancale Andrea A
Antiviral chemistry & chemotherapy 20151201 5-6
<h4>Background</h4>Despite the great progress made in the last 10 years, alternative strategies might help improving definitive treatment options against hepatitis C virus infection.<h4>Methods</h4>With the aim of identifying novel inhibitors of the hepatitis C virus-1b replication targeting the viral NS3 helicase, the structures of previously reported symmetrical inhibitors of this enzyme were rationally modified, and according to docking-based studies, four novel scaffolds were selected for sy ...[more]