Ontology highlight
ABSTRACT:
SUBMITTER: Miguel-Avila J
PROVIDER: S-EPMC5892125 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chemical science 20180115 7
The archetype reaction of "click" chemistry, namely, the copper-promoted azide-alkyne cycloaddition (CuAAC), has found an impressive number of applications in biological chemistry. However, methods for promoting intermolecular annulations of exogenous, small azides and alkynes in the complex interior of mammalian cells, are essentially unknown. Herein we demonstrate that isolated, well-defined copper(i)-tris(triazolyl) complexes featuring designed ligands can readily enter mammalian cells and pr ...[more]