Radiation-induced cognitive toxicity: pathophysiology and interventions to reduce toxicity in adults.
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ABSTRACT:
SUBMITTER: Wilke C
PROVIDER: S-EPMC5892147 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Radiation-induced cognitive toxicity: pathophysiology and interventions to reduce toxicity in adults.
Wilke Christopher C Grosshans David D Duman Joseph J Brown Paul P Li Jing J
Neuro-oncology 20180401 5
Radiotherapy is ubiquitous in the treatment of patients with both primary brain tumors as well as disease which is metastatic to the brain. This therapy is not without cost, however, as cognitive decline is frequently associated with cranial radiation, particularly with whole brain radiotherapy (WBRT). The precise mechanisms responsible for radiation-induced morbidity remain incompletely understood and continue to be an active area of ongoing research. In this article, we review the hypothetical ...[more]
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