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Novel Latency Reversal Agents for HIV-1 Cure.

ABSTRACT: Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART is not curative owing to the persistence of replication-competent, latent proviruses in long-lived resting T cells. Strategies that target these latently infected cells and allow immune recognition and clearance of this reservoir will be necessary to eradicate HIV-1 in infected individuals. This review describes current pharmacologic approaches to reactivate the latent reservoir so that infected cells can be recognized and targeted, with the ultimate goal of achieving an HIV-1 cure.

SUBMITTER: Spivak AM

PROVIDER: S-EPMC5892446 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Novel Latency Reversal Agents for HIV-1 Cure.

Spivak Adam M AM Planelles Vicente V

Annual review of medicine 20171103

Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART is not curative owing to the persistence of replication-competent, latent proviruses in long-lived resting T cells. Strategies that target these latently infected cells and allow immune recognition and clearance of this reservoir will be necessary to eradicate HIV-1 in infected individuals. This review describes current pharmacologic approaches to reactivate the latent reservoir so that infected cells can ...[more]

PMID: 29099677

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