Ontology highlight
ABSTRACT:
SUBMITTER: Spivak AM
PROVIDER: S-EPMC5892446 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Spivak Adam M AM Planelles Vicente V
Annual review of medicine 20171103
Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART is not curative owing to the persistence of replication-competent, latent proviruses in long-lived resting T cells. Strategies that target these latently infected cells and allow immune recognition and clearance of this reservoir will be necessary to eradicate HIV-1 in infected individuals. This review describes current pharmacologic approaches to reactivate the latent reservoir so that infected cells can ...[more]