Increased formate overflow is a hallmark of oxidative cancer.
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ABSTRACT:
SUBMITTER: Meiser J
PROVIDER: S-EPMC5893600 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Increased formate overflow is a hallmark of oxidative cancer.
Meiser Johannes J Schuster Anne A Pietzke Matthias M Vande Voorde Johan J Athineos Dimitris D Oizel Kristell K Burgos-Barragan Guillermo G Wit Niek N Dhayade Sandeep S Morton Jennifer P JP Dornier Emmanuel E Sumpton David D Mackay Gillian M GM Blyth Karen K Patel Ketan J KJ Niclou Simone P SP Vazquez Alexei A
Nature communications 20180410 1
Formate overflow coupled to mitochondrial oxidative metabolism\ has been observed in cancer cell lines, but whether that takes place in the tumor microenvironment is not known. Here we report the observation of serine catabolism to formate in normal murine tissues, with a relative rate correlating with serine levels and the tissue oxidative state. Yet, serine catabolism to formate is increased in the transformed tissue of in vivo models of intestinal adenomas and mammary carcinomas. The increase ...[more]
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