Ontology highlight
ABSTRACT:
SUBMITTER: Schomel N
PROVIDER: S-EPMC7234995 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Schömel Nina N Gruber Lisa L Alexopoulos Stephanie J SJ Trautmann Sandra S Olzomer Ellen M EM Byrne Frances L FL Hoehn Kyle L KL Gurke Robert R Thomas Dominique D Ferreirós Nerea N Geisslinger Gerd G Wegner Marthe-Susanna MS
Scientific reports 20200518 1
The only enzyme in the glycosphingolipid (GSL) metabolic pathway, which produces glucosylceramide (GlcCer) de novo is UDP-glucose ceramide glucosyltransferase (UGCG). UGCG is linked to pro-cancerous processes such as multidrug resistance development and increased proliferation in several cancer types. Previously, we showed an UGCG-dependent glutamine metabolism adaption to nutrient-poor environment of breast cancer cells. This adaption includes reinforced oxidative stress response and fueling th ...[more]