Ontology highlight
ABSTRACT:
SUBMITTER: Stephan G
PROVIDER: S-EPMC5893604 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Stephan Gabriele G Huang Lumei L Tang Yong Y Vilotti Sandra S Fabbretti Elsa E Yu Ye Y Nörenberg Wolfgang W Franke Heike H Gölöncsér Flóra F Sperlágh Beáta B Dopychai Anke A Hausmann Ralf R Schmalzing Günther G Rubini Patrizia P Illes Peter P
Nature communications 20180410 1
Two subclasses of acid-sensing ion channels (ASIC3) and of ATP-sensitive P2X receptors (P2X3Rs) show a partially overlapping expression in sensory neurons. Here we report that both recombinant and native receptors interact with each other in multiple ways. Current measurements with the patch-clamp technique prove that ASIC3 stimulation strongly inhibits the P2X3R current partly by a Ca<sup>2+</sup>-dependent mechanism. The proton-binding site is critical for this effect and the two receptor chan ...[more]