Ontology highlight
ABSTRACT:
SUBMITTER: Pagani G
PROVIDER: S-EPMC5893634 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Pagani Giulia G Gohlke Holger H
Scientific reports 20180410 1
Integrins are α/β heterodimeric transmembrane adhesion receptors. Evidence exists that their transmembrane domain (TMD) separates upon activation. Subunit-specific differences in activation sensitivity of integrins were reported. However, whether sequence variations in the TMD lead to differential TMD association has remained elusive. Here, we show by molecular dynamics simulations and association free energy calculations on TMDs of integrin α<sub>IIb</sub>β<sub>3</sub>, α<sub>v</sub>β<sub>3</su ...[more]